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Network of paper people

Information for patients

What is alcoholic hepatitis?

Alcoholic hepatitis (AH) is a form of alcohol-related liver disease. It is characterised by liver failure due to recent and heavy alcohol consumption.


How are patients diagnosed with alcoholic hepatitis?

Liver biopsy is currently the method used to diagnose alcoholic hepatitis. It is difficult to predict the course of the disease and how to select the best treatment for each patient. In this condition, one third of patients have died within three months and half of patients have died at a year.

What is the purpose of the research project? 

The purpose of this study is to investigate how we can reduce mortality in patients with alcoholic hepatitis. We will be collecting samples and data from patients. These samples and data will be used to investigate whether a blood test can diagnose alcoholic hepatitis and so avoid the need for liver biopsy. The study will also investigate how healthcare professionals can predict disease outcome, patient infection and patient kidney damage.

What are the possible benefits of the clinical studies (ISAIAH and MICAH) included in this project? 

The knowledge we gain from the studies should help us improve the treatment offered to patients with alcohol-related liver disease in the future. Collecting patient samples for analysis in the laboratory is key to achieving this.

What will happen to the results of the research studies?

The results of clinical studies may take approximately 1 year to be reported.  The results will be published in medical journals and presented at international scientific conferences. Patients that have participated in the studies will not be identified in any report or publication. The results are important as they may answer several questions for doctors looking after patients with severe alcoholic hepatitis and could improve treatment for patients in the future.

Who is organising and funding the research?

Imperial Clinical Trials Unit is managing the day-to-day running of the studies. The Unit have a wealth of experience expertise running clinical studies. The Sponsor of the clinical studies is Imperial College London. The funding body financially supporting the consortium is the Medical Research Council. The study was designed by Professor Mark Thursz who is an expert in liver diseases.

Where to find more information about alcoholic hepatitis

For any further questions about the disease or clinical trials, patients should discuss them with their healthcare professional. Patients may find it helpful to contact the British Liver Trust, who have a website and publications about the liver and liver disease. The British Liver Trust also have a helpline here.